Research Group in Bioinformatics
Biological research at AWI in the field of biodiversity, biomineralisation, temparature adaptation and others is becoming more and more involved with the use of biological information systems such as genome and proteome databases combined with several tools for information query, management and mapping. The research group in Bioinformatics, as part of the scientific computing group of AWI's computing center, was established in 2004 as a facility to provide services requiring bioinformatics and data analysis background. The group provides access to databases and develops new algorithms and integrated software for the use in scientific environments such as the molecular genetics laboratories in house. In co-operation with Hochschule Bremerhaven and others, students are able to work in the field of algorithmics and software development, participating in scientific projects at AWI.
The group also provides technical support and infrastructure for the hosting of databases and applications running on compute systems such as high-performance Linux-clusters installed at the computing center.
Research topics
The bioinformatics working group participates in data analyses in diverse projects at the AWI in phylogenetics, phylogenomics, population genetics, EST and phylochip analyses. Protein targeting and identification of signal-peptides is a further topic of the group in evolution research. We also support research in chemical structure prediction by means of NMR, cluster analysis of mass spectra (LC/MS). This is complemented by research based on molecular dynamics simulations. Within the AWI research program PACES the group contributes insights into evolutionary adaptation to cold climate, characterising cold-active enzymes by their biophysical properties, in their proteomic context. Recently we identified the relevant physical parameters of amino-acids to characterise and discriminate cold-adaptation of enzymes on the sequence level in proteomic and protein-family comparative studies. Thermal adaptation appears to have physical, and thus universal consequences for the dynamics of biodiversity.
Tool development
Our software development projects include:
- the standalone phylogenetic annotation tool PhyloGena
- the software PhylochipAnalyzer for the analysis of phylochips with hierarchical probes
- in the field of workflow software for sequence analysis, we develop and integrate tools into the Staden-package
- for the cluster-analysis of molecular dynamics dihedral angles a set of R-scripts has been placed here as supplemental material to the paper in JCC/2009
See our software page for more information.
ARB support
We support ARB (www.arb-home.de) for molecular phylogeny. For example, we help with installation, database merging etc.
Course Material
next statistics course is in Dec. 14-16. 2009





