Recent research focuses on the role of dysregulated pH for cancer progression and monitoring of intracellular organelles like endosomes and lysosomes. pH indicators are widely used in cell biology applications. Ageladine A, a new natural product from a marine sponge, overcomes some limitations and disadvantages of known pH sensitive fluorescent dyes making it an excellent new tool for life sciences applications

High membrane permeability: 15 minutes incubation time for cells

Wide range from pH 4 – pH 9

All experiments can be done with standard laboratory equipment

Stable and non toxic even after several days of incubation

Slow photobleaching

Applications: Fluorescence microscopy (living cells, tissues, small animals), frozen sections. Flow cytometry: (not tested yet)